Antiapoptotic effects of erythropoietin in differentiated neuroblastoma sh-sy5y cells require activation of both the stat5 and akt signaling pathways*

HIGHLIGHTS

• who: Moonkyoung Um from the suggest that the importance of the NF-␬B signaling pathway in Epo signaling varied in different cell typesRole of the EpoR in Antiapoptotic Activity of Epo in Neuronal Cells- Recent reports suggested that the cytoprotective effects of Epo may be separated from its hematopoietic effects through signaling by an alternative receptor (59). Instead of the "classical" homodimeric EpoR complex, a heterotrimer complex consisting of an EpoR monomer and a dimer of the common ␤ chain was suggested to be responsible for Epo cytoprotective effects. By using the PrlR/EpoR chimera system, we show . . .
  

   

  

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