Antibiotic-induced gut microbiota disruption promotes vascular calcification by reducing short-chain fatty acid acetate

HIGHLIGHTS

  • What: As graphically summarized in Figure 8, the authors demonstrate for the first time that ABX and vancomycin can exacerbate vascular calcification by disrupting GM. The study shows that supplementation with acetate has the potential to alleviate vascular calcification, which may be an important target for future treatment of vascular calcification.
  • Who: Shi-Yu Zeng and colleagues from the All experimental animals were conducted in accordance with the Chineses animal protection law and the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory AnimalsThe experimental animal protocols were reviewed and approved . . .

     

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