Antibody targeting of e3 ubiquitin ligases for receptor degradation

HIGHLIGHTS

• who: Hadir Marei from the (UNIVERSITY) have published the paper: Antibody targeting of E3 ubiquitin ligases for receptor degradation, in the Journal: (JOURNAL) of 12/08/2022
• what: Focusing on zinc- and ring finger 3 (ZNRF3), a Wnt-responsive ligase, the authors show that this approach can enable colorectal cancer-specific degradation. By examining a matrix of additional cell-surface E3 ubiquitin ligases and transmembrane receptors, the authors demonstrate that this technology is amendable for u2018on-demand` degradation. Identification of Wnt-responsive ligases Among the cell-surface E3 ubiquitin ligases, the authors focused on ring . . .
  

   

  

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