Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability

HIGHLIGHTS

  • What: The authors show that fluid-phase endocytosis is a key target pathway for concentration-dependent modulation by most SSRIs and some other ADs. The authors provide key evidence filling this knowledge gap by showing that most if not all of currently prescribed SSRIs are capable of rapidly regulating membrane trafficking. In contrast, the study has focused on the lower end of therapeutic concentration range, which is characterized by high tolerability and strong dose-response relationship in the clinic .
  • Who: Wenjia Du from the (UNIVERSITY) have published the research work: Antidepressant-induced membrane trafficking regulates . . .

     

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