Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

HIGHLIGHTS

  • What: The authors show that the iron chelating pyoverdines siderophores produced by environmental Pseudomonas spp. have strong antibacterial properties by inducing iron starvation and growth arrest in pathogens. For these reasons, the authors propose that pyoverdines from non-pathogenic Pseudomonas spp. could be potent agents to reduce the growth of opportunistic human pathogens by intensifying iron competition. The authors propose that pyoverdine treatment could synergistically interact with the host innate immune system.
  • Who: Evolutionary Biology and collaborators from the Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland • Department of Chemistry have published the research . . .

     

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