Antimir targeting of microrna-134 reduces seizures in a mouse model of angelman syndrome

HIGHLIGHTS

• who: Aoife Campbell from the RCSI University have published the Article: AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome, in the Journal: (JOURNAL) of 28/06/2022
• what: AS is caused by mutations or deletion of the maternal copy of the paternally imprinted UBE3A gene with current precision therapy approaches focusing on re-expression of UBE3A. The authors report levels of miR-134 and key targets are normal in the hippocampus of mice carrying a maternal deletion of Ube3a (Ube3am/p+). The authors show that silencing miR-134 can . . .
  

   

  

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