HIGHLIGHTS
SUMMARY
A second source of free_radicals is represented by different oxidases such as xanthine oxidase (XO) and NADPH oxidases (NOX), multi-subunit enzyme complexes that are located in the cell membrane and expressed in CNS cells, including neurons and glial cells. ROS is a general term that includes all reactive forms of O2, both the radical species such as the superoxide radical (O2. - ) and the hydroxyl radical 3 of 23 (OH. ) as well as the non-radical species such as the hydrogen peroxide (H2 O2 ) and the singlet oxygen (1 O2 ), which can be converted . . .
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