Apobec3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types

HIGHLIGHTS

• who: G. Maria Jakobsdottir from the (UNIVERSITY) have published the research: APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types, in the Journal: (JOURNAL)
• what: The authors provide evidence that supports a model of cancer genome evolution in which acts as a causative factor in the development of diverse and widespread genomic instability through the generation of double strand breaks. The models show that tumours carrying APOBEC3 mutations are more genomically unstable and that the number of APOBEC3 mutations is associated with all measures of genomic instability, except the . . .
  

   

  

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