HIGHLIGHTS
- who: Rosalu00eda Fernu00e1ndez-Calle from the Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, Lund, Sweden have published the research: APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimeru2019s disease pathology and brain diseases, in the Journal: (JOURNAL)
SUMMARY
In the amyloidogenic pathway, APP is cleaved by β-secretase (also known as BACE-1), producing soluble APPβ (sAPPβ) and membrane-bound C-terminal 99 or 89 amino_acid fragments, also known as β-CTF. Cleavage of APP CTFs leads to the extracellular secretion of Aβ peptides mainly composed of . . .
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