Apoe interacts with ace2 inhibiting sars-cov-2 cellular entry and inflammation in covid-19 patients

HIGHLIGHTS

• who: Hongsheng Zhang from the The purpose of this study was to define how APOE protein and its isoforms affect the SARS-Co, virus entry, and whether and how APOE u03b5, allele may increase susceptibility and severity of COVID- Experiments include in vitro and in vivo pseudo-viral entry and protein interaction assessments. Pseudo-viral entry analyses include confocal imaging, flow cytometry analyses and quantitative real-time PCR (qRT-PCR). Protein interaction assays include protein pull-down assay, Bio-Layer-Interferometry assay, live-cell surface staining, stimulated emission depletion microcopy (STED), and immuno-electron microscopy. APOE allele . . .
  

   

  

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