Apolipoprotein e4 stimulates camp response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway*

HIGHLIGHTS

• who: Nobutaka Ohkubo from the (UNIVERSITY) have published the research: Apolipoprotein E4 Stimulates cAMP Response Element-binding Protein Transcriptional Activity through the Extracellular Signal-regulated Kinase Pathway*, in the Journal: (JOURNAL) of June/12,/2000
• what: In this report, the authors demonstrate that apoE4 stimulates the transcriptional activity of cAMP-response element-binding protein (CREB) by activating the extracellular signalregulated kinase (ERK) cascade in rat primary hippocampal neurons.
• how: Assuming that neurotoxicity is caused by calcium influx following apoE treatment the data are consistent with the data provided by Tolar et_al in that . . .
  

   

  

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