Apoptosis as a barrier against cin and aneuploidy

HIGHLIGHTS

• who: Johannes G. Weiss et al. from the Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria have published the research: Apoptosis as a Barrier against CIN and Aneuploidy, in the Journal: Cancers 2022, x of 21/Dec/2022
• what: The authors aim to review the established links between the cell cycle and apoptotic cell death machinery in response to delayed mitosis, chromosome alterations or defective cytokinesis, acting as a barrier to malignant transformation and therapy-resistance. The authors focus on the connections between the SAC and the mitochondrial pathway of apoptosis.
 



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