Application of cleavable linkers to improve therapeutic index of radioligand therapies

HIGHLIGHTS

  • who: Joseph Lau and collaborators from the Department of Molecular Oncology, BC Cancer, Vancouver, BC V Z , Canada Department of Radiology, University of Pennsylvania Perelman School of Medicine have published the research: Application of Cleavable Linkers to Improve Therapeutic Index of Radioligand Therapies, in the Journal: Molecules 2022, 27, 4959. of /2022/
  • what: The study shows that incorporation of a hydrophobic amino_acid with a bulky side chain group is favourable for enhancing enzymolysis efficiency. group is favourable for enhancing enzymolysis efficiency.
  • how: In this review the authors will review established and emerging strategies . . .

     

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