Application of the adverse outcome pathway concept to in vitro nephrotoxicity assessment: kidney injury due to receptor-mediated endocytosis and lysosomal overload as a case study

HIGHLIGHTS

• who: Nephrotoxicity Assessment and collaborators from the United Kingdom Department of, of Wu00fcrzburg, Wu00fcrzburg, Germany, Fraunhofer Institute for Molecular Biology and Applied have published the Article: Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study, in the Journal: (JOURNAL)
• what: The authors used the AOP of proximal tubule injury initiated by_(receptor-mediated) endocytosis and lysosomal overload (Mally and Jarzina, 2022) as a case study to adopt the AOP concept for systemic toxicity testing and risk assessment based . . .
  

   

  

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