Applications and prospects of cryo-em in drug discovery

HIGHLIGHTS

• who: Kong-Fu Zhu from the Department of Biomedical Engineering, Southern University of Science and, Shenzhen, Guangdong, China have published the Article: Applications and prospects of cryo-EM in drug discovery, in the Journal: (JOURNAL)
• what: The authors aim to provide an overview of how cryo-EM techniques are applied to facilitate discovery. Structural analysis showed that the main reason for the failure to develop u03b3-secretase inhibitors is that u03b3-secretase inhibitors lack specificity or have weak selectivity for APP and Notch proteolysis, thus cannot specifically inhibit APP binding .
• future: Modern AI . . .
  

   

  

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