HIGHLIGHTS
SUMMARY
Inadomi et_al demonstrated that PPI use is largely inappropriate and costly, rendering strategies that allow for adequate selection of patients who actually benefit from therapy with these drugs a priority of health systems. Multiple guidelines and campaigns promote discontinuation of PPIs when possible, usage of the minimum effective dose, and pursuing alternative diagnoses or treatments in patients whose symptoms do not respond to PPI therapy. Determination of gastric function, including acid output and infection with HP, are useful tools to guide the clinician in evaluating gastric morphology and function, and represent an invaluable tool . . .
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