Aptamer-gemcitabine conjugates with enzymatically cleavable linker for targeted delivery and intracellular drug release in cancer cells

HIGHLIGHTS

  • who: Jianjun Qi and collaborators from the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Fannin Street have published the paper: Aptamer-Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells, in the Journal: Pharmaceuticals 2022, 15, x FOR PEER REVIEW of 13/04/2022
  • what: The study demonstrates a novel approach to aptamer-mediated targeted drug delivery that combines a high drug payload and an enzymatically controlled drug release switch to achieve higher therapeutic efficacy and fewer off-target effects relative to free-drug chemotherapy. The . . .

     

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