Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy

HIGHLIGHTS

  • who: August et al. from the Oslo University Hospital, Norway AandF University, China have published the article: Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy, in the Journal: (JOURNAL)
  • what: The authors demonstrated that AQP8 induced autophagy by transporting H2O2 into granulosa cells during follicular atresia.
  • how: For this experiment 5-6-week-old female mice were used. Showed that the cellular H2O2 level was significantly higher in the granulosa cells of the Aqp8+/+ mice than that in those of the Aqp8-/- mice indicating the involvement of AQP8 in H2O2
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