Ar cooperates with smad4 to maintain skeletal muscle homeostasis

HIGHLIGHTS

• who: Mitra Forouhan from the Department of Paediatrics, University of Oxford, South Parks Road, Oxford , QX, UK have published the paper: AR cooperates with SMAD4 to maintain skeletal muscle homeostasis, in the Journal: (JOURNAL)
• what: The authors show that upon activation AR forms a complex with SMAD4 to orchestrate a hypertrophy programme by modulating SMAD4 chromatin binding dynamics and enhancing its transactivation activity. The experiment was conducted using 300 u03bcg of chromatin and 14 u03bcg of anti-mouse Smad4 (B-8) (Santa Cruz, sc-7966) or anti-mouse IgG1 isotype control (Cell Signaling Technology, 5415 . . .
  

   

  

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