HIGHLIGHTS
SUMMARY
Histologically, grade II (low-grade) diffuse gliomas display nuclear Frontiers in Genetics frontiersin.org 10.3389/fgene.2023.1027690 Lipid peroxidation, which preferentially oxidizes polyunsaturated_fatty_acids, has been involved in the etiology of diverse pathological conditions such as diabetes and cancers (Anthonymuthu et_al, 2016; Kuo et_al, 2016; Zivkovic et_al, 2017). ALOX5 is a non-heme ironcontaining dioxygenase that encodes lipoxygenase and metabolizes AA into hydroperoxyderivatives (5-HPETE) and further into 5-hydroxyeicosatetraenoic acid (5-HETE), conferring growth, invasion, and chemopreventive advantage in cancer cells (Tang J. et_al, 2021; Zhang et_al, 2022). Frontiers in Genetics Drug . . .
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