HIGHLIGHTS
- who: Top from the School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China have published the paper: are more sensitive to platinum-based chemotherapy: a meta-, in the Journal: (JOURNAL) of September/21,/2016
SUMMARY
Excision Repair Cross-Complementation Group 5 gene (ERCC5, 13q33.1) encodes a critical DNA repair enzyme involved in nucleotide excision repair (NER) function. Scattered evidences indicate the variants of the ERCC5 rs1047768 (T335C, His46His) polymorphism could yield differing survival outcomes, despite being a coding-synonymous polymorphism. The amino-acid substitution caused Platinum-based chemotherapies are regarded . . .
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