HIGHLIGHTS
- who: Chao Ma from the United States University of Texas at San Antonio have published the paper: Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis, in the Journal: (JOURNAL)
- how: The results showed that reduced Arg1 levels in LysM positive cells promoted amyloidosis in CNS.
- future: Since the myeloid marker gene Lyz2 targets both macrophages and microglia the observed consequence of exacerbated amyloidosis from this study were possibly attributed to the deficiency of Arg1 in both brain resident microglia and CNS infiltrated macrophages. It remains . . .
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