Arginine methylation of the histone h3 tail impedes effector binding*

HIGHLIGHTS

• who: Aimee N. Iberg from the (UNIVERSITY) have published the research work: Arginine Methylation of the Histone H3 Tail Impedes Effector Binding*, in the Journal: (JOURNAL) of December/11,/2007
• what: The authors show that H3 tail binding effector proteins are indeed sensitive to H3R2 methylation and that PRMT6, not CARM1/PRMT4, is the primary methyltransferase acting on this site. The authors show that PRMT6, an enzyme with restricted nuclear localization , and not CARM1, methylates H3R2 in_vitro, and H3R2 methylation is still present in CARM1-null embryos.

SUMMARY

Proteins bind H3K4 . . .

 



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