HIGHLIGHTS
- who: Anne Fernandez-Vidal and colleagues from the (UNIVERSITY) have published the research: Around and beyond 53BP1 Nuclear Bodies, in the Journal: (JOURNAL)
- what: This work shows that depletion of ANLN, a major cytokinesis regulator, progressively increased 53BP1 NBs at the next G1 phases where daughter nuclei reside in the same cytoplasm due to cytokinesis failure, while harboring RS hallmarks during S phase.
SUMMARY
To these numerous small foci, 53BP1 has also been involved in different large NBs as telomere dysfunction-induced foci (TIFs), DNA segments with chromatin alterations reinforcing senescence . . .
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