Artificial tethering of lc3 or p62 to organelles is not sufficient to trigger autophagy

HIGHLIGHTS

• who: Friedemann Loos from the (UNIVERSITY) have published the research: Artificial tethering of LC3 or p62 to organelles is not sufficient to trigger autophagy, in the Journal: (JOURNAL)
• what: The authors show that this system can be used to successfully enforce the subcellular shuttling of functional LC3 and p62, yet fails to stimulate bona fide autophagy. The authors report the development of a chemical-biological tool kit allowing to target GFP- and SBP-tagged LC3 or p62 (the "baits") to distinct subcellular locations such as the ER and the Golgi decorated with streptavidin moieties (the . . .
  

   

  

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