HIGHLIGHTS
- who: Shaghayegh Nouruzi from the University of have published the research work: ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors investigate the epigenetic landscape of CRPC after ENZ treatment by profiling global chromatin accessibility to uncover the earliest factors that drive cellular plasticity and commitment to the neuroendocrine lineage. The authors report here that remodeling of the chromatin by ARPIs was coupled with increase expression and activity of ASCL1. The work provides basis for targeting transcription . . .
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