HIGHLIGHTS
- who: Cristina Banella and colleagues from the Department of Health Sciences, Meyer Children`s University Hospital, Florence, Italy have published the article: Ascorbate Plus Buformin in AML: A Metabolic Targeted Treatment, in the Journal: (JOURNAL)
- what: The authors characterized the metabolic background of different Leukemias` (AMLs) cells and described a heterogeneous and highly flexible energetic metabolism. The authors show that ascorbate inhibits glycolysis through interfering with HK1/2 and functions in hematopoietic cells. The authors compared the metabolic pathways underlying the different stages of differentiation of normal myeloid progenitors/precursors with that of primary blasts . . .
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