HIGHLIGHTS
SUMMARY
In the late 1990s, the golden dream of chemists to perform chemical transformations in living systems raised interest in a set of chemical reactions that are selective without interfering with native biochemical processes. At the same time Sharpless laboratory introduced the concept of click chemistry as a "set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries". Since 2002, the "ligation" Cu(I)-catalyzed regioselective "ligation" of catalyzed azide-alkyne cycloaddition (CuAAC)-reported independently by Meldal and azides with alkynes-i.e., Cu(I)-catalyzed . . .
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