Assembly pathway of hepatitis b core virus-like particles from genetically fused dimers*

HIGHLIGHTS

• who: Kris Holmes from the work, it appears that this species is on pathwayHowever, assembly may also continue via tetrameric and pentameric intermediates. The structure of the trimer of dimers here remains unknown. It is possible that it is a closed ring of subunits (Fig., ). However, it is tempting to speculate that it is an open structure, more competent to allow addition of further subunits i.e. corresponding to part of a, fold particle axis. The presence of putative tetrameric and pentameric intermediates (identified here by mass spectrometry) would strongly support this. Using a related strategy, we . . .
  

   

  

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