HIGHLIGHTS
- who: Stefan R. Marsden and colleagues from the (UNIVERSITY) have published the research work: Assessing the Thiamine Diphosphate Dependent Pyruvate Dehydrogenase E1 Subunit for Carboligation Reactions with Aliphatic Ketoacids, in the Journal: (JOURNAL)
- what: The authors show that EcPDH E1 is a promising biocatalyst for the production of chiral u03b1-hydroxyketones. The alternate thermodynamically controlled self-reaction of aliphatic aldehydes was shown to be limited to low levels of conversion which the authors propose to be due to their large hydration constants.
SUMMARY
The holoenzyme is usually a homodimer with two . . .
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