Assessment of pabpn1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy

HIGHLIGHTS

• who: Fanny Roth from the (UNIVERSITY) have published the Article: Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy, in the Journal: (JOURNAL)
• what: The authors demonstrate that age and genotype influence PABPN1 aggregates: the percentage of myonuclei containing PABPN1 aggregates increases with age and the chaperone HSP70 co-localize more frequently with PABPN1 aggregates with a larger polyalanine tract. The authors have studied the correlation between nuclear aggregates, nuclear size, genotype and age of the patients and using HSP70 co-staining the . . .
  

   

  

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