HIGHLIGHTS
- who: Yan Dora Zhang from the (UNIVERSITY) have published the research work: Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: By incorporating age-specific incidence29 from population-based cancer registries, the authors explore the magnitude of absolute risk stratification potentially achievable by PRS.
- how: The authors analyzed summary data from GWAS studies across 14 cancer types.
- future: Studies of ancestry- and subtype-specific genetic architectures are needed to address these limitations.
SUMMARY
Specific . . .
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