HIGHLIGHTS
SUMMARY
MARCH7 (Membrane Associated RING-CH 7), also known as axotrophin, belongs to the MARCH family of E3 ubiquitin ligases which add ubiquitin on target proteins, to signal their vesicular transfer amongst membrane compartments. A report indicated that deficiency of MARCH7 potentiates proliferation and T_cell-derived Leukemia inhibitory factor (LIH) secretion in T-cells upon mitogen stimulation, signifying that MARCH7 plays important roles in immune tolerance. Silencing of MARCH7 was found to decrease ovarian cancer cell proliferation, migration, and invasion and prevent ovarian cancer growth in mice. Hu et_al, 2018 observed the involvement of MARCH7 . . .
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