Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of s-ketamine

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  • who: Lena Vera Danyeli from the Study design and participants A randomized, placebo-controlled, double-blind cross-over study was conducted to examine the association between the immediate and delayed functional connectivity and metabolic changes induced by a single subanesthetic, ketamine infusion in thirty-five healthy male participants (mean age u00b1 standard deviation (SD)=, u00b1, ., years). Since, ketamine is approved as an add-on treatment in treatment-resistant depression (TRD), the majority of patients are already on antidepressant medication when starting, ketamine treatment. Healthy participants were therefore chosen to allow for investigations without confounding effects of an . . .

     

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