Astragaloside vi ameliorates post-stroke depression via upregulating the nrg-1-mediated mek/erk pathway

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SUMMARY

    The reduction of endogenous NRG-1 exacerbates neuronal injury in_vivo. As the major metabolite of astragalosides, AsVI promotes the skin cells` proliferation and migration by activating EGFR/ERK signaling pathway in_vitro and accelerating the cure of sterile and infected wounds in_vivo. To test this hypothesis, the authors constructed the in_vivo PSD rat model by stimulating the middle cerebral artery occlusion (MCAO) stroke model ensured by chronic unpredictable mild stress (CUMS) and established the in_vitro major depression cellular model by incubating PC-12 cells with corticosterone (CORT). To test the effects of AsVI on PSD . . .

     

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