HIGHLIGHTS
SUMMARY
A. mongholicus and P. montana have potential hypoglycemic effects in diabetic animals (Hsu et_al, 2003; Wang et_al, 2009). In this study, the hypoglycemic effects and underlying mechanism of APF were investigated in a classic STZ + HFD induced T2DM mice, leptin deficient diabetic ob/ob mice and STZ induced T1DM mice (Kusakabe et_al, 2009; Muzzin et_al, 1996). Although the balance of adipoinsular axis is crucial for energy homeostasis, leptin and insulin sensitivity may be suppressed by some endogenetic signailing pathways (Taniguchi et_al, 2006; Balland and Cowley, 2015). PTP1B and TCPTP contribute to insulin resistance (Galic . . .
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