Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory t cell numbers and protects against pathological neuroinflammation

HIGHLIGHTS

• who: Lidia Yshii from the Department University, Babraham Research Campus, Cambridge, United Kingdom have published the Article: Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation, in the Journal: (JOURNAL) of 11/04/2022
• what: The authors demonstrate the highly efficacious control of neuroinflammation by CNS-based IL-2 using a synthetic biological circuit to drive local production of IL-2 while leaving the peripheral immune system intact. The authors provide a solution to the biologic delivery problem for the brain with an adeno . . .
  

   

  

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