Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

HIGHLIGHTS

  • who: Marta Sidoryk-Wegrzynowicz from the Neurons and astrocytes were prepared from postnatal day, or, P S tau or P L tau female and male mice [1, ] along with age-matched C BL/, control miceThe tau mutation in the P S mice is in the human N R isoform whereas in the P L mice, it is in the N R isoform. Brain extracts were prepared from , to , month-old P S and C BL/, mice. This research was conducted under the Animals (Scientific Procedures) Act, Amendment Regulations, following ethical review by the University of Cambridge Animal . . .

     

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