Astrocytic function is associated with both amyloid-β and tau pathology in non-demented apoe ε4 carriers

HIGHLIGHTS

• who: Nicola Spotorno and collaborators from the (UNIVERSITY) have published the research: Astrocytic function is associated with both amyloid-u03b2 and tau pathology in non-demented APOE u03b54 carriers, in the Journal: (JOURNAL)
• what: The authors explored the interaction between APOE, astrocytes and protein aggregation focusing on non-demented individuals, including Au03b2-negative cognitively unimpaired individuals, Au03b2-positive cognitively unimpaired individuals (preclinical Alzheimer`s disease) and Au03b2-positive patients with mild cognitive impairment (MCI) (prodromal Alzheimer`s disease). When introducing APOE genotype in the model, the authors found a significant interaction between APOE and mIns . . .
  

   

  

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