HIGHLIGHTS
SUMMARY
In recent years, accessible regions bound by transcription factors (TFs) have been considered to be the reason for differences in gene_expression and were involved in further determining gonadal fates. Based on the relationship between chromatin accessibility and gene_expression, it is important to understand the dynamic patterns and regulatory functions of open chromatin regions in chicken sex differentiation and sex reversal. The authors discovered the relationship between gene_expression and chromatin accessibility during chicken sex reversal, and identified that the expression levels of numerous candidate genes and cis-regulatory elements, such as DMRT1, SOX9, TOX3, FOXL2 . . .
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