Atheroprone fluid shear stress-regulated alk1-endoglin-smad signaling originates from early endosomes

HIGHLIGHTS

• who: Paul-Lennard Mendez from the (UNIVERSITY) have published the research: Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes, in the Journal: (JOURNAL)
• what: The authors report here that knock-down of Endoglin leads to exacerbated SMAD1/5 phosphorylation and atherou2011 prone gene expression profile in HUVECs sheared for 24 h. The authors demonstrate that Endoglin possesses a protective role in the vascular endothelium by preventing excessive BMP9-ALK1 signaling and subsequent expression of EDN1. To validate this approach, the authors first evaluated whether human umbilical vein ECs (HUVECs) exposed . . .
  

   

  

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