Atm inhibitor ku60019 synergistically sensitizes lung cancer cells to topoisomerase ii poisons by multiple mechanisms

HIGHLIGHTS

• who: Jianfeng Shu from the HwaMei HospitalUniversity of China have published the Article: ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms, in the Journal: Scientific Reports Scientific Reports
• what: Next, the authors explore whether KU60019 could block ATM activity by interfering with binding to TOP2u03b2 and thereby whether KU60019 could prevent TOP2u03b2 from being ubiquitinated. Next, the authors investigate whether KU60019 could enhance VP-16-mediated suppression of survival in lung cancer cells. The authors demonstrate the following: 1) KU60019, an ATM inhibitor interferes with the association of . . .
  

   

  

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