HIGHLIGHTS
- who: Elisa Focchi from the (UNIVERSITY) have published the paper: ATM rules neurodevelopment and glutamatergic transmission in the hippocampus but not in the cortex, in the Journal: (JOURNAL) of 12/07/2021
- what: Starting from the pharmacological evidence that the control of cognitive defects in Atm heterozygous (Atm+/-) and knockout (Atm-/-) mice is achieved by delivering the selective serotonin reuptake inhibitor Fluoxetine (Fluox), the authors demonstrate that ATM differentially regulates hippocampal and cortical development as well as synaptic properties. The authors demonstrate that the increased amount of KCC2 leads to the accumulation of presynaptic KARs . . .
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