Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin

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• who: Alexis Dumortier et al. from the Ecole Polytechnique Fédérale de Lausanne (EPFL SV ISREC), Lausanne, Switzerland, Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne have published the research work: Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin, in the Journal: CSL (RBP-J) to activate target gene expression [4]. of February/18,/2010
• what: The authors demonstrate that skin-specific inactivation of Notch1 and Notch2 simultaneously or RBP-J induces the development of a severe form of atopic dermatitis . . .
  

   

  

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