HIGHLIGHTS
- who: Jerzy Majka from the (UNIVERSITY) have published the paper: ATP Hydrolysis by RAD50 Protein Switches MRE11 Enzyme from Endonuclease to Exonuclease*, in the Journal: (JOURNAL) of January/20,/2012
- what: The authors report here that RAD50 coordinates these two activities of MRE11 by ATP-dependent structural rearrangements and a remarkable ability to switch MRE11 nucleolytic activity. Based on the nucleotide dynamics of RAD50, the authors propose a testable model in which the structural changes integrate the nucleolytic processing of MRE11 and the tethering functions of RAD50-MRE11 to direct pathway choice.
SUMMARY . . .
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