HIGHLIGHTS
- who: Rakkreat Wikiniyadhanee et al. from the Mahidol University, Bang Phli, Samutprakarn, Thailand have published the research: ATR Inhibitor Synergizes PARP Inhibitor Cytotoxicity in Homologous Recombination Repair Deficiency TK6 Cell Lines, in the Journal: BioMed Research International of 29/09/2022
- what: The aim of this study is to investigate the synergy of the different combinations of PARP inhibitors (olaparib talazoparib or veliparib) and ATR inhibitor AZD6738. The authors show that combining PARP inhibitors with AZD6738 contributes to an increase in replication-associated DNA damage and micronucleus induction. This study showed novel opportunities for PARP . . .
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