HIGHLIGHTS
SUMMARY
The biological activity of drugs relies on the ability to interact with enzymes and receptors, mainly changing the activity of a selected active_site. Chiral organic molecules interact differently with the active_sites of enzymes in different chemical-physical ways to favor specific spatial conformations. Positions 2 and 5 of pyrrole are occupied by p-fluorophenyl and isopropyl groups, respectively; position of pyrrole are by occupied by amide p-fluorophenyl and3isopropyl groups, respectively; position 4 is occupied a phenyl and position by a phenyl group. ZPE-corrected free_energy has been reported. With this a Suzuki couplingstrategy . . .
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