Attenuated g protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics

HIGHLIGHTS

• who: Pooja Dasgupta from the DepartmentJena University have published the paper: Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics, in the Journal: Scientific Reports Scientific Reports
• what: The authors assessed the in_vitro pharmacological effects of these chemically diverse novel mixed MOP/ NOP agonists on agonist-induced G protein signaling and receptor phosphorylation.

SUMMARY

Radioligand displacement competition binding and GTPγ35S binding functional assays were conducted in Chinese hamster ovary (CHO) cells stably expressing human NOP and MOP opioid receptors individually, as . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or Email

Password

Remember me

Lost your password?

If you don't have an account, you can create one here.