Atx-lpa-dependent nuclear translocation of endonuclease g in respiratory epithelial cells: a new mode action for dna damage induced by crystalline silica particles

HIGHLIGHTS

  • who: Huiyuan Zheng et al. from the Institute of Environmental Medicine, Karolinska Institutet, Box, Stockholm, Sweden have published the article: ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles, in the Journal: Cancers 2023, 15, 865. of /2023/
  • what: The authors provide in vitro and in vivo evidence that this signaling pathway triggers endonuclease G (EndoG) translocation from the mitochondria to the nucleus. The authors show that low doses of CSi rapidly increase nuclear levels of EndoG in_vitro and in_vivo . . .

     

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