Auf-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through auf-1–dicer-1–mir-122 hierarchy

HIGHLIGHTS

  • who: Oishika Das and colleagues from the Qingdao University Medical College, China have published the Article: AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1u2013Dicer-1u2013mir-122 hierarchy, in the Journal: (JOURNAL)
  • what: This study determines that gut-derived butyrate flux affects metabolic phenotype through miRNAs, Dicer-1, AUF-1, and cholesterol metabolic enzymes and controls cholesterol homeostasis. To ensure the viability of the cells at higher doses of butyrate, the authors performed an MTT assay where the authors show that more than 85% of Huh7 cells were viable at . . .

     

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